Implication of IL-18 in chronic inflammation of severe refractory asthma
نویسندگان
چکیده
Background Bronchial asthma is traditionally viewed as an eosinophilic airway inflammatory disorder with the involvement of Th2 cytokines. In refractory asthma, where chronic inflammation and airway remodeling are key pathological features, it is suggested that the dysregulation of the Th1/Th2 cytokines production modifies airway inflammation and airway hyperrespnsiveness (AHR). Interleukin (IL)-18, a pleiotropic proinflammatory cytokine, contributes to the pathophysiology of asthma by modulating airway inflammation. Aim of this study was to investigate IL-18 levels in refractory asthma and its relation to eosinophilic airway inflammation and airway remodelling.
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عنوان ژورنال:
دوره 5 شماره
صفحات -
تاریخ انتشار 2015